myosin light chain kinase การใช้

• The encoded protein binds calcium and is activated by myosin light chain kinase.
• The myosin light chain phosphatase is inhibited to increase the gain or sensitivity of myosin light chain kinase to calcium.
• RLC is phosphorylated by a cardiac-specific myosin light chain kinase ( MYLK3 ), which was recently cloned.
• This gene encodes a myosin light chain kinase, a calcium / calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.
• This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium / calmodulin dependent enzyme.
• The combination of decreased intracellular calcium, increased membrane potassium conductance, and decreased myosin light chain kinase activity leads to smooth muscle relaxation and bronchodilation.
• The gene " MYLK ", a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium / calmodulin dependent enzyme.
• Because of its origin as the C-terminal end of smooth muscle myosin light chain kinase, it is called " telokin " ( from a combination of the Greek telos, " end " and kinase ).
• Upon saturation of Ca2 +, Calmodulin undergoes a conformation change allowing it to bind with a target protein such as skMLCK . An image depicting a similar complex ( sdCen / skMLCK2 ) is shown under myosin light chain kinase.
• Downstream effectors of NRG-1 / ErbB, include cardiac-specific myosin light chain kinase ( cMLCK ), Protein Phosphatase type 1 ( PP1 ), sarcoplasmic reticulum Ca2 +-ATPase 2 ( SERCA2 ), and focal adhesion kinase ( FAK ).
• In addition, using a separate promoter in an intron in the 3'region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments.
• Telokin is an acidic protein with a PI value of 4-5 and 17-kDa with an amino acid sequence that is identical to the C terminus of the 130-kDa myosin light chain kinase ( MLCK ), although it is expressed as a separate protein and produced by an alternate promoter of the MLCK gene.
• Human ALC-2 is phosphorylated at its N-terminus at Serine-15 by a cardiac-specific myosin light chain kinase; interestingly, ALC-2 has a Serine at position 14, which is an Asparagine in the atrial muscle was shown to be modulated by enhanced phosphorylation of ALC-2 by myosin light chain kinase.
• Human ALC-2 is phosphorylated at its N-terminus at Serine-15 by a cardiac-specific myosin light chain kinase; interestingly, ALC-2 has a Serine at position 14, which is an Asparagine in the atrial muscle was shown to be modulated by enhanced phosphorylation of ALC-2 by myosin light chain kinase.